Dawn Out of the Darkness

Out of darkness.

Cutaneous lupus vulgaris: Bringing the wolf out of the darkness

Lupus vulgaris is the commonest form of cutaneous tuberculosis accounting for about 75% of the cases. Clinical dermatologists need to be aware of the myriad clinical presentations of this condition as it can be misdiagnosed especially when the index of suspicion is low. It is important to make a diagnosis and promptly treat as it can be disfiguring and destructive. Introduction Tuberculosis (TB...

Antiprotozoals for human African trypanosomiasis: the heart of darkness at dawn

In December 2012 the WHO convened an expert meeting on elimination of human African trypanosomiasis (HAT; sleeping sickness). The participants concluded that the decision to eliminate the disease should be maintained with a goal of elimination as a public health problem by 2020 and absence of transmission resulting in zero cases reported in all discrete geographic areas of endemicity, or ‘foci’...

Out of darkness: long non-coding RNAs come of age

It has been known for a number of years that only about 2% of this RNA encodes proteins. However, numerous studies employing both tiling arrays and high-throughput sequencing found that the genome is pervasively transcribed, with most DNA copied, at least at some point in time, into RNA. Indeed, Birney et al. (2007) estimated that 93% of the human genome is transcribed. Because of a dearth of f...

The Dawn of Galaxies ∗

The development of primordial inhomogeneities into the non-linear regime and the formation of the first astrophysical objects within dark matter halos mark the transition from a simple, neutral, cooling universe – described by just a few parameters – to a messy ionized one – the realm of radiative, hydrodynamic, and star formation processes. The recent measurement by the WMAP satellite of a lar...